Yazar "Bähr, Mathias" için listeleme
-
CCL11 differentially affects post-stroke brain injury and neuroregeneration in mice depending on age
Lieschke, Simone; Zechmeister, Bozena; Haupt, Matteo; Zheng, Xuan; Jin, Fengyan; Hein, Katharina; Weber, Martin S.; Hermann, Dirk M.; Bähr, Mathias; Kılıç, Ertuğrul; Doeppner, Thorsten R. (MDPI, 2020)CCL11 has recently been shown to differentially affect cell survival under various pathological conditions including stroke. Indeed, CCL11 promotes neuroregeneration in neonatal stroke mice. The impact of CCL11 on the adult ... -
In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model
Kelmanson, Ilya V.; Shokhina, Arina G.; Kotova, Daria A.; Pochechuev, Matvei S.; Ivanovaa, Alexandra D.; Kostyuka, Alexander I.; Panova, Anastasiya S.; Borodinova, Anastasia A.; Solotenkovc, Maxim A.; Stepanov, Evgeny A.; Raevskiia, Roman I.; Moshchenko, Aleksandr A.; Pak, Valeriy V.; Ermakova, Yulia G.; van Belle, Gijsbert J.C.; Tarabykin, Viktor; Balaban, Pavel M.; Fedotov, Ilya V.; Fedotov, Andrei B.; Conrad, Marcus; Bogeski, Ivan; Katschinski, Dörthe M.; Doeppner, Thorsten R.; Bähr, Mathias; Zheltikov, Aleksei M.; Belousov, Vsevolod V.; Bilan, Dmitry S. (Elsevier B.V., 2021)Ischemic cerebral stroke is one of the leading causes of death and disability in humans. However, molecular processes underlying the development of this pathology remain poorly understood. There are major gaps in our ... -
Knockdown of NEAT1 prevents post-stroke lipid droplet agglomeration in microglia by regulating autophagy
Pan, Yongli; Xin, Wenqiang; Wei, Wei; Tatenhorst, Lars; Graf, Irina; Popa-Wagner, Aurel; Gerner, Stefan T.; Huber, Sabine E.; Kılıç, Ertuğrul; Hermann, Dirk M.; Bähr, Mathias; Huttner, Hagen B.; Doeppner, Thorsten Roland (Springer Science and Business Media Deutschland GmbH, 2024)Background: Lipid droplets (LD), lipid-storing organelles containing neutral lipids like glycerolipids and cholesterol, are increasingly accepted as hallmarks of inflammation. The nuclear paraspeckle assembly transcript 1 ... -
Neuroprotective strategies for ischemic stroke—Future perspectives
Haupt, Matteo; Gerner, Stefan T.; Bähr, Mathias; Doeppner, Thorsten R. (MDPI, 2023)Ischemic stroke is the main cause of death and the most common cause of acquired physical disability worldwide. Recent demographic changes increase the relevance of stroke and its sequelae. The acute treatment for stroke ... -
Preconditioned extracellular vesicles from hypoxic microglia reduce poststroke AQP4 depolarization, disturbed cerebrospinal fluid flow, astrogliosis, and neuroinflammation
Xin, Wenqiang; Pan, Yongli; Wei, Wei; Tatenhorst, Lars; Graf, Irina; Popa-Wagner, Aurel; Gerner, Stefan T.; Huber, Sabine; Kılıç, Ertuğrul; Hermann, Dirk M.; Bähr, Mathias; Huttner, Hagen B.; Doeppner, Thorsten Roland (NLM (Medline), 2023)Background: Stroke stimulates reactive astrogliosis, aquaporin 4 (AQP4) depolarization and neuroinflammation. Preconditioned extracellular vesicles (EVs) from microglia exposed to hypoxia, in turn, reduce poststroke brain ... -
Quest for quality in translational stroke research––a new dawn for neuroprotection?
Haupt, Matteo; Gerner, Stefan T.; Bähr, Mathias; Doeppner, Thorsten R. (Multidisciplinary Digital Publishing Institute, 2022)Despite tremendous progress in modern‐day stroke therapy, ischemic stroke remains a disease associated with a high socioeconomic burden in industrialized countries. In light of demo-graphic change, these health care costs ...